Blar i forfatter "Andersen, Toril"

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    • Chitosan in Mucoadhesive Drug Delivery: Focus on Local Vaginal Therapy 

      Andersen, Toril; Bleher, Stefan; Flaten, Gøril Eide; Tho, Ingunn; Mattsson, Sofia; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-01-07)
      Mucoadhesive drug therapy destined for localized drug treatment is gaining increasing importance in today’s drug development. Chitosan, due to its known biodegradability, bioadhesiveness and excellent safety profile offers means to improve mucosal drug therapy. We have used chitosan as mucoadhesive polymer to develop liposomes able to ensure prolonged residence time at vaginal site. Two types of ...

    • Chitosan-Based Nanomedicine to Fight Genital Candida Infections: Chitosomes 

      Andersen, Toril; Mishchenko, Ekaterina; Flaten, Gøril Eide; Sollid, Johanna U Ericson; Mattsson, Sofia; Tho, Ingunn; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-04)
      Vaginal infections are associated with high recurrence, which is often due to a lack of efficient treatment of complex vaginal infections comprised of several types of pathogens, especially fungi and bacteria. Chitosan, a mucoadhesive polymer with known antifungal effect, could offer a great improvement in vaginal therapy; the chitosan-based nanosystem could both provide antifungal effects and ...

    • Isolation and characterization of wax esters from Calanus finmarchicus 

      Andersen, Toril (Master thesis; Mastergradsoppgave, 2010-06-16)
      Calanus finmarchicus is a vast resource that until recently have been exploited to a minimal degree only. In the last few years harvesting and processing methods have been developed. There is a large market and great interest in products derived from marine oils. Most of the products today are derived from organisms at a high trophic level, i.e. products derived from cod liver oil. One disadvantage ...

    • Novel chitosan-containing liposomes as mucoadhesive delivery system for vaginal administration 

      Andersen, Toril (Doctoral thesis; Doktorgradsavhandling, 2015-10-02)
      Treatment of vaginal infections remains unsuccessful due to recurrent infections and limited patient compliance. Current therapies are unable to penetrate bacterial and fungal biofilms, allowing the survival of microorganisms, which often leads to new infections. Local administration of drug is able to provide a higher drug concentration at the vaginal site; enabling the administration of lower drug ...

    • Pectosomes and Chitosomes as Delivery Systems for Metronidazole: The One-Pot Preparation Method 

      Andersen, Toril; Vanic, Zeljka; Flaten, Gøril Eide; Mattsson, S.; Tho, Ingunn; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Mucoadhesive liposomes offer a potential for improved residence time of liposomal systems targeting contact with mucosal tissues, such as in buccal, oral, colon, and vaginal drug delivery. Most of the currently available methods rely on the coating of preformed liposomes by various mucoadhesive polymers. The aim of this study was to develop novel mucoadhesive system by the one-pot preparation method. ...